Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting rhoa regulation Academic Article uri icon

Overview

MeSH Major

  • Cholesterol
  • Foam Cells
  • Macrophage Activation
  • rhoA GTP-Binding Protein

abstract

  • These results suggest that increases in plasma membrane cholesterol content alter RhoA activation, resulting in inhibition of cell migration. These findings provide one possible explanation for the retention of foam cells in atherosclerotic lesions.

publication date

  • July 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.107.145086

PubMed ID

  • 17495238

Additional Document Info

start page

  • 1596

end page

  • 602

volume

  • 27

number

  • 7