ANCA Are Detectable in Nearly All Patients with Active Severe Wegener's Granulomatosis
Antibodies, Antineutrophil Cytoplasmic
Granulomatosis with Polyangiitis
ANCA are detectable in nearly all patients with active severe Wegener's granulomatosis, but approximately 1 of 5 patients with active limited disease are ANCA negative. Immunofluorescence and both direct and capture ELISAs are required for optimal detection, suggesting that ANCA are not recognized equally well by all testing methods.