AKT/PKB Signaling: Navigating Downstream Review uri icon

Overview

MeSH Major

  • Proto-Oncogene Proteins c-akt
  • Signal Transduction

abstract

  • The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approaches used to characterize its true cellular targets. In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration.

publication date

  • June 29, 2007

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2756685

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2007.06.009

PubMed ID

  • 17604717

Additional Document Info

start page

  • 1261

end page

  • 74

volume

  • 129

number

  • 7