Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial Academic Article Article uri icon

Overview

MeSH Major

  • Brain
  • Parkinson Disease
  • Placebo Effect

abstract

  • AAV-GAD gene therapy of the subthalamic nucleus is safe and well tolerated by patients with advanced Parkinson's disease, suggesting that in-vivo gene therapy in the adult brain might be safe for various neurodegenerative diseases.

publication date

  • June 23, 2007

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(07)60982-9

PubMed ID

  • 17586305

Additional Document Info

start page

  • 2097

end page

  • 105

volume

  • 369

number

  • 9579