Sex differences in autoimmune disease Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases

abstract

  • Female/male ratios of autoimmune diseases range from 10:1 to 1:3, with similar severity between the sexes. Men and women respond similarly to the infection and to vaccination, arguing against intrinsic sex differences in immune response. In autoimmune-like illnesses caused by environmental agents sex discrepancy is explained by differences in exposure. Endogenous hormones could cause sex discrepancy if their effect is a threshold off-on switch rather than quantitatively variable. X-inactivation and imprinting could cause sex discrepancy. Other possibilities include chronobiologic differences and pregnancy and menstruation biologies in which men differ from women.

publication date

  • December 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1177/0961203306069353

PubMed ID

  • 17153846

Additional Document Info

start page

  • 753

end page

  • 6

volume

  • 15

number

  • 11