The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Review uri icon

Overview

MeSH

  • Animals
  • Genes, Immediate-Early
  • Herpesvirus 4, Human
  • Humans
  • Promoter Regions, Genetic
  • Rhadinovirus
  • Transcriptional Activation
  • Virus Activation

MeSH Major

  • Herpesvirus 8, Human
  • Immediate-Early Proteins
  • Trans-Activators
  • Viral Proteins

abstract

  • The replication and transcription activator protein, Rta, is encoded by Orf50 in Kaposi's sarcoma-associated herpesvirus (KSHV) and other known gammaherpesviruses including Epstein-Barr virus (EBV), rhesus rhadinovirus (RRV), herpesvirus saimiri (HVS), and murine herpesvirus 68 (MHV-68). Each Rta/Orf50 homologue of each gammaherpesvirus plays a pivotal role in the initiation of viral lytic gene expression and lytic reactivation from latency. Here we discuss the Rta/Orf50 of KSHV in comparison to the Rta/Orf50s of other gammaherpesviruses in an effort to identify structural motifs, mechanisms of action, and modulating host factors.

publication date

  • 2007

has subject area

  • Animals
  • Genes, Immediate-Early
  • Herpesvirus 4, Human
  • Herpesvirus 8, Human
  • Humans
  • Immediate-Early Proteins
  • Promoter Regions, Genetic
  • Rhadinovirus
  • Trans-Activators
  • Transcriptional Activation
  • Viral Proteins
  • Virus Activation

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 17089794

Additional Document Info

start page

  • 71

end page

  • 100

volume

  • 312