PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia Academic Article uri icon


MeSH Major

  • Phthalazines
  • Primary Myelofibrosis
  • Protein Kinase Inhibitors
  • Pyridines
  • Vascular Endothelial Growth Factor A


  • Angiogenesis is part of the pathophysiology of myelofibrosis with myeloid metaplasia (MMM). PTK787/ZK 222584 (PTK/ZK) is a novel inhibitor of vascular endothelial growth factor receptors. Twenty-nine patients with MMM received a continuous dosing schedule of PTK/ZK doses of 500 or 750 mg twice daily (BID). Transient potentially PTK/ZK related mild nausea, vomiting, dizziness, fatigue, thrombocytopenia, or anorexia occurred in 15% of patients. Dose limiting toxicities of dyspepsia, proteinurea, and/or mucositis were observed in patients treated with 750 mg BID. One (3%) and five (17%) patients achieved complete remission and clinical improvement, respectively. PTK/ZK has modest activity in patients with MMM.

publication date

  • July 2007



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.leukres.2006.12.001

PubMed ID

  • 17560285

Additional Document Info

start page

  • 891

end page

  • 7


  • 31


  • 7