A CERTain Role for Ceramide in Taxane-Induced Cell Death Article uri icon

Overview

MeSH Major

  • Cell Death
  • Ceramides
  • Drug Resistance, Neoplasm
  • Paclitaxel
  • Protein-Serine-Threonine Kinases

abstract

  • An unexpected benefit of functional genomic screens is that at times they answer questions that they were not designed to ask. A siRNA screen reported by Swanton et al. in this issue of Cancer Cell reveals that silencing of spindle assembly checkpoint genes facilitates mitotic slippage, resulting in escape from taxane-induced cell death, aneuploidy, and chromosomal instability, hallmarks of taxane resistance. Unexpectedly, the screen disclosed that the sphingolipid ceramide is a key regulator of the taxane-mediated spindle assembly checkpoint and taxane-induced cell death. Ceramide metabolism thus serves as a legitimate target for modulation of taxane effect on tumors.

publication date

  • June 12, 2007

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2007.05.003

Additional Document Info

start page

  • 473

end page

  • 5

volume

  • 11

number

  • 6