The folate receptor α is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate
Academic Article
Overview
MeSH Major
Bone Neoplasms
Carrier Proteins
Osteosarcoma
Receptors, Cell Surface
Tetrahydrofolates
abstract
This study suggests that FR alpha plays a role in the uptake of 5-methyltetrahydrofolate when the concentration gradient is insufficient for RFC-mediated transport. FR alpha overexpression is unlikely secondary to the decreased RFC expression in osteosarcoma.
