The folate receptor α is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate Academic Article uri icon

Overview

MeSH Major

  • Bone Neoplasms
  • Carrier Proteins
  • Osteosarcoma
  • Receptors, Cell Surface
  • Tetrahydrofolates

abstract

  • This study suggests that FR alpha plays a role in the uptake of 5-methyltetrahydrofolate when the concentration gradient is insufficient for RFC-mediated transport. FR alpha overexpression is unlikely secondary to the decreased RFC expression in osteosarcoma.

publication date

  • May 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-1343

PubMed ID

  • 17473184

Additional Document Info

start page

  • 2557

end page

  • 67

volume

  • 13

number

  • 9