Breast cancer from oral and transdermal estradiol: A cohort study of Finnish women Academic Article uri icon


MeSH Major

  • Autoradiography
  • Biopsy
  • Fluorodeoxyglucose F18
  • Positron-Emission Tomography
  • Tomography, X-Ray Computed


  • Evaluation of: Lyytinen H, Pukkala E, Ylikorkala O: Breast cancer risk in postmenopausal women using estrogen-only therapy. Obstet. Gynecol. 108(6), 1354-1360 (2006) [1] . A cohort study of 84,729 Finnish women over the age of 50 years who used oral or transdermal estradiol for at least 6 months, followed for the incidence of breast cancer using a national cancer registry. The study was conducted to evaluate whether the risk of breast cancer with estrogen-only therapy varies by dose, constituents or route of administration. A total of 2171 women developed breast cancer, with no increased risk observed for less than 5 years of use, and some risk for greater than 5 years of use for both oral and transdermal routes of administration.

publication date

  • May 2007



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.2217/17455057.3.3.321

PubMed ID

  • 19803991

Additional Document Info

start page

  • 321

end page

  • 4


  • 3


  • 3