Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF Academic Article uri icon


MeSH Major

  • B-Lymphocytes
  • DNA-Binding Proteins
  • Hematopoietic Stem Cells
  • Lymphopoiesis
  • Proto-Oncogenes
  • Receptors, Notch
  • T-Lymphocytes
  • Transcription Factors


  • Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.

publication date

  • May 11, 2007



  • Academic Article



  • eng

PubMed Central ID

  • PMC2978506

Digital Object Identifier (DOI)

  • 10.1126/science.1140881

PubMed ID

  • 17495164

Additional Document Info

start page

  • 860

end page

  • 6


  • 316


  • 5826