Mast Cell-Derived Cathepsin g: A Possible Role in The Adverse Remodeling of The Failing Human Heart Academic Article uri icon

Overview

MeSH Major

  • Cardiac Output, Low
  • Cathepsins
  • Mast Cells
  • Serine Endopeptidases
  • Ventricular Remodeling

abstract

  • Heart failure causes an increase of myocardial MCs. We have provided evidence that cathepsin g positive MCs accumulate during heart failure and their total percentage decreases after ventricular unloading. This coincides with the decrease in myocyte necrosis, hypertrophy, and fibrosis. Thus, cathepsin g may play a role in the progression to heart failure by activating angiotensin II, leading to detrimental effects on the heart.

publication date

  • May 15, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jss.2007.02.040

PubMed ID

  • 17418861

Additional Document Info

start page

  • 199

end page

  • 203

volume

  • 140

number

  • 2