Identification of angiogenesis/metastases genes predicting chemoradiotherapy response in patients with laryngopharyngeal carcinoma Academic Article uri icon

Overview

MeSH Major

  • Gene Expression Profiling
  • Genes, Neoplasm
  • Laryngeal Neoplasms
  • Neoplasm Metastasis
  • Neovascularization, Pathologic
  • Pharyngeal Neoplasms

abstract

  • Genomic screening by cDNA microarray and validation internally by real-time RT-PCR and externally by immunohistochemistry have identified two genes (MDM2 and erbB2) as predictors of locoregional failure in LPC patients treated with CRT. The role of these genes in treatment selection and the functional basis for their activity in CRT response merit additional consideration.

publication date

  • April 10, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2005.05.3397

PubMed ID

  • 17416856

Additional Document Info

start page

  • 1369

end page

  • 76

volume

  • 25

number

  • 11