Immune cross-reactivity in celiac disease: Anti-gliadin antibodies bind to neuronal synapsin I Academic Article uri icon

Overview

MeSH Major

  • Autoantibodies
  • Binding Sites, Antibody
  • Celiac Disease
  • Gliadin
  • Neurons
  • Synapsins

abstract

  • Celiac disease is an immune-mediated disorder triggered by ingestion of wheat gliadin and related proteins in genetically susceptible individuals. In addition to the characteristic enteropathy, celiac disease is associated with various extraintestinal manifestations, including neurologic complications such as neuropathy, ataxia, seizures, and neurobehavioral changes. The cause of the neurologic manifestations is unknown, but autoimmunity resulting from molecular mimicry between gliadin and nervous system proteins has been proposed to play a role. In this study, we sought to investigate the immune reactivity of the anti-gliadin Ab response toward neural proteins. We characterized the binding of affinity-purified anti-gliadin Abs from immunized animals to brain proteins by one- and two-dimensional gel electrophoresis, immunoblotting, and peptide mass mapping. The major immunoreactive protein was identified as synapsin I. Anti-gliadin Abs from patients with celiac disease also bound to the protein. Such cross-reactivity may provide clues into the pathogenic mechanism of the neurologic deficits that are associated with gluten sensitivity.

publication date

  • May 15, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 17475890

Additional Document Info

start page

  • 6590

end page

  • 5

volume

  • 178

number

  • 10