A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis Academic Article uri icon

Overview

MeSH Major

  • Dynamin I
  • Endocytosis
  • Neurons
  • Synapses
  • Synaptic Vesicles

abstract

  • Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.

publication date

  • April 27, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1140621

PubMed ID

  • 17463283

Additional Document Info

start page

  • 570

end page

  • 4

volume

  • 316

number

  • 5824