Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor Academic Article uri icon

Overview

MeSH Major

  • Carotid Arteries
  • Carotid Artery Diseases
  • Cathepsins
  • Microscopy, Fluorescence
  • Spectroscopy, Near-Infrared

abstract

  • Use of this novel protease-activatable NIRF agent for optical imaging in vivo demonstrated preferential localization of enzymatically active CatK to macrophages, consistent with their known greater elastinolytic capabilities compared with smooth muscle cells. Augmented CatK proteolysis in atheromata further links CatK to vascular remodeling and plaque vulnerability.

publication date

  • May 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.106.660340

PubMed ID

  • 17420353

Additional Document Info

start page

  • 2292

end page

  • 8

volume

  • 115

number

  • 17