Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae Academic Article uri icon

Overview

MeSH Major

  • Behavior, Animal
  • Dendrites
  • Drosophila melanogaster
  • Locomotion
  • Neurons, Afferent

abstract

  • From breathing to walking, rhythmic movements encompass physiological processes important across the entire animal kingdom. It is thought by many that the generation of rhythmic behavior is operated by a central pattern generator (CPG) and does not require peripheral sensory input. Sensory feedback is, however, required to modify or coordinate the motor activity in response to the circumstances of actual movement. In contrast to this notion, we report here that sensory input is necessary for the generation of Drosophila larval locomotion, a form of rhythmic behavior. Blockage of all peripheral sensory inputs resulted in cessation of larval crawling. By conditionally silencing various subsets of larval peripheral sensory neurons, we identified the multiple dendritic (MD) neurons as the neurons essential for the generation of rhythmic peristaltic locomotion. By recording the locomotive motor activities, we further demonstrate that removal of MD neuron input disrupted rhythmic motor firing pattern in a way that prolonged the stereotyped segmental motor firing duration and prevented the propagation of posterior to anterior segmental motor firing. These findings reveal that MD sensory neuron input is a necessary component in the neural circuitry that generates larval locomotion.

publication date

  • March 20, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1820883

Digital Object Identifier (DOI)

  • 10.1073/pnas.0700895104

PubMed ID

  • 17360325

Additional Document Info

start page

  • 5199

end page

  • 204

volume

  • 104

number

  • 12