Quantitative objective markers for upper and lower motor neuron dysfunction in ALS Academic Article uri icon

Overview

MeSH Major

  • Amyotrophic Lateral Sclerosis
  • Aspartic Acid
  • Creatine
  • Motor Cortex
  • Motor Neuron Disease
  • Motor Neurons
  • Muscular Atrophy, Spinal

abstract

  • (1)H MR spectroscopic imaging measures of the primary motor cortex N-acetyl-aspartate (NAA) concentration and ratio of NAA to creatine, central motor conduction time to the tibialis anterior, and motor unit number estimation significantly differed between ALS, its subsets, and control subjects, suggesting they have potential to provide insight into the pathobiology of these disorders.

publication date

  • April 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1212/01.wnl.0000260065.57832.87

PubMed ID

  • 17452585

Additional Document Info

start page

  • 1402

end page

  • 10

volume

  • 68

number

  • 17