Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
Amyotrophic Lateral Sclerosis
Motor Neuron Disease
Muscular Atrophy, Spinal
(1)H MR spectroscopic imaging measures of the primary motor cortex N-acetyl-aspartate (NAA) concentration and ratio of NAA to creatine, central motor conduction time to the tibialis anterior, and motor unit number estimation significantly differed between ALS, its subsets, and control subjects, suggesting they have potential to provide insight into the pathobiology of these disorders.