Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry Academic Article uri icon

Overview

MeSH Major

  • Bone and Bones
  • Dinosaurs
  • Elephants
  • Fossils
  • Mass Spectrometry
  • Proteins
  • Reptilian Proteins

abstract

  • Fossilized bones from extinct taxa harbor the potential for obtaining protein or DNA sequences that could reveal evolutionary links to extant species. We used mass spectrometry to obtain protein sequences from bones of a 160,000- to 600,000-year-old extinct mastodon (Mammut americanum) and a 68-million-year-old dinosaur (Tyrannosaurus rex). The presence of T. rex sequences indicates that their peptide bonds were remarkably stable. Mass spectrometry can thus be used to determine unique sequences from ancient organisms from peptide fragmentation patterns, a valuable tool to study the evolution and adaptation of ancient taxa from which genomic sequences are unlikely to be obtained.

publication date

  • April 13, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1137614

PubMed ID

  • 17431180

Additional Document Info

start page

  • 280

end page

  • 5

volume

  • 316

number

  • 5822