AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo Academic Article uri icon

Overview

MeSH Major

  • Blood Vessels
  • Endothelium, Vascular
  • Proto-Oncogene Proteins c-akt
  • Skin

abstract

  • Inhibition of Akt signaling may be useful in the treatment of vascular malformations. Examination of problematic hemangiomas and vascular malformations for the presence of activated Akt or downstream targets of Akt, such as mammalian target of rapamycin (mTOR), may predict response to treatment with Akt inhibitors or rapamycin. This study provides a potential rationale for the systemic and topical use of these inhibitors for vascular malformations and hemangiomas.

publication date

  • April 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1001/archderm.143.4.504

PubMed ID

  • 17438183

Additional Document Info

start page

  • 504

end page

  • 6

volume

  • 143

number

  • 4