NOx and ADMA changes with focal ischemia, amelioration with the chaperonin GroEL Academic Article uri icon


MeSH Major

  • Arginine
  • Brain
  • Brain Ischemia
  • Cerebrovascular Circulation
  • Chaperonin 60
  • Nitric Oxide


  • Both nitric oxide and asymmetric dimethylarginine (ADMA) play a critical role in the regulation of cerebral blood flow, though their neuroprotective and cytotoxic effects are still under investigation. In this study, we found that nitrate/nitrite (NOx) levels in plasma, ischemic brain tissue, and cerebrospinal fluid (CSF) increased significantly 24h after 2h transient middle cerebral artery occlusion (MCAO) in rats. ADMA levels were unchanged in plasma, but decreased significantly in CSF 24h following MCAO. The CSF ADMA/NOx ratio decreased markedly following ischemia. Rats protected by expression of the chaperonin GroEL or its folding deficient mutant D87K had lower plasma NOx levels at 24h reperfusion. ADMA, NO, and their ratio in CSF merit further study as biomarkers for ischemic brain injury.

publication date

  • May 17, 2007



  • Academic Article



  • eng

PubMed Central ID

  • PMC2430977

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2007.03.021

PubMed ID

  • 17398004

Additional Document Info

start page

  • 201

end page

  • 4


  • 418


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