Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: Role of shear stress and the cAMP/protein kinase A pathway
Bone Morphogenetic Proteins
Cyclic AMP-Dependent Protein Kinases
Laminar shear stress and the cAMP/PKA pathway are important negative regulators of BMP-4 expression in the vascular endothelium. Because BMP-4 elicits endothelial activation and dysfunction, hypertension, and vascular calcification, inhibition of BMP-4 expression by shear stress and the cAMP/PKA pathway is likely to exert antiatherogenic and vasculoprotective effects.