Antibodies to West Nile Virus: A Double-Edged Sword Article uri icon

Overview

MeSH Major

  • Antibodies, Viral
  • West Nile virus

abstract

  • Antibodies, although critical for host defense against West Nile virus (WNV), can both neutralize and enhance viral infection. In this issue of Cell Host & Microbe, Pierson et al. dissect these opposing effects and demonstrate that, when 120 epitopes are available per WNV virion, approximately 25 are occupied by antibody at 50% neutralization. At lower occupancies, enhancement of infection dominates; at higher ones, neutralization ensues. These results are important for WNV vaccine design and for potential therapeutic use of antibodies to WNV.

publication date

  • April 19, 2007

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2007.04.001

Additional Document Info

start page

  • 87

end page

  • 9

volume

  • 1

number

  • 2