Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease Academic Article uri icon


MeSH Major

  • Carcinoma, Renal Cell
  • Cerebellar Neoplasms
  • Hemangioblastoma
  • Kidney Neoplasms
  • Spinal Cord Neoplasms
  • von Hippel-Lindau Disease


  • A case of metastatic renal cell carcinoma (RCC) to a capillary hemangioblastoma (HAB) of the central nervous system in a 52-year-old woman with von Hippel-Lindau (vHL) syndrome is described. We review the literature on metastatic RCC to HAB, summarize the histologic and immunohistochemical features that can distinguish between the 2 tumors, and comment on the significance of such a finding in terms of the clinical diagnosis of vHL. We found the expression of CAM 5.2, RCC antigen, and CD10 to be strong in RCC and absent in HAB and, conversely, staining with Leu-7, neural cell adhesion molecule, and inhibin-alpha was present in HAB but weak or absent in RCC. These antibodies can be used to differentiate these entities, provided one is astute in recognizing the possibility of their coexistence.

publication date

  • April 2007



  • Academic Article



  • eng

PubMed ID

  • 17425399

Additional Document Info

start page

  • 641

end page

  • 5


  • 131


  • 4