Cooperative effect of cell-cycle regulators expression on bladder cancer development and biologic aggressiveness Academic Article uri icon


MeSH Major

  • Carcinoma, Transitional Cell
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Tumor Suppressor Protein p53
  • Urinary Bladder Neoplasms


  • The aim of this study was to evaluate the association between p53, p21, p27 and Rb expression, alone or in combination, with pathological features and clinical outcomes of urothelial carcinoma of the bladder. Immunohistochemical staining for p53, p21, p27 and pRB was performed on tissue microarrays comprising normal urothelium from nine controls, transurethral resection specimens from 74 patients with Ta, Tis and/or T1 bladder urothelial carcinoma, radical cystectomy specimens from 226 consecutive urothelial carcinoma patients, and lymph nodes with tumor invasion from 50 of the 226 cystectomy patients. All nine controls had normal status of biomarkers. The proportion of biomarkers alterations was highest in lymph node metastases. p53, pRB and p27 were associated with pathologic stage, lymphovascular invasion and lymph node metastases (P-values

publication date

  • April 2007



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1038/modpathol.3800757

PubMed ID

  • 17384651

Additional Document Info

start page

  • 445

end page

  • 59


  • 20


  • 4