Renal function and risk for cardiovascular events in type 2 diabetic patients with hypertension: The RENAAL and LIFE studies
Diabetes Mellitus, Type 2
A progressively higher risk for the composite cardiovascular endpoint was observed with incremental baseline serum creatinine in type 2 diabetic patients with hypertension, even within the normal range. Thus, there appears to be no serum creatinine threshold level for an increased cardiovascular risk. Baseline serum creatinine was a major independent risk factor for cardiovascular disease (www.ClinicalTrials.gov number NCT00308347).