The clinical spectrum of catastrophic antiphospholipid syndrome in the absence and presence of lupus. Article uri icon

Overview

MeSH

  • Adult
  • Catastrophic Illness
  • Comorbidity
  • Female
  • Global Health
  • Humans
  • International Cooperation
  • Internet
  • Logistic Models
  • Male
  • Prognosis
  • Registries
  • Survival Rate

MeSH Major

  • Antiphospholipid Syndrome
  • Lupus Erythematosus, Systemic

abstract

  • To compare the clinical spectrum of patients with primary catastrophic antiphospholipid syndrome (P-CAPS) to those with systemic lupus erythematosus-associated CAPS (SLE-CAPS). We used the Internet-based CAPS Registry to compare the demographic, clinical, and laboratory characteristics of 127 P-CAPS patients to 103 SLE-CAPS patients. In a logistic regression analysis, we also determined the poor prognostic factors for mortality. At the time of CAPS diagnosis, compared to patients with P-CAPS, those with SLE-CAPS were more likely to be female and younger; have cerebral and pancreatic involvement; receive corticosteroids and cyclophosphamide; demonstrate a lower prevalence of high titer (> or = 80 U) IgG anticardiolipin antibody; and have a higher risk for mortality after adjusting for age, sex, organ involvement, and treatment. Based on a logistic regression analysis, cyclophosphamide use was associated with increased mortality in P-CAPS but improved survival in SLE-CAPS patients. SLE is a poor prognostic factor in patients with CAPS and cyclophosphamide may be beneficial in those with SLE-CAPS.

publication date

  • February 2007

has subject area

  • Adult
  • Antiphospholipid Syndrome
  • Catastrophic Illness
  • Comorbidity
  • Female
  • Global Health
  • Humans
  • International Cooperation
  • Internet
  • Logistic Models
  • Lupus Erythematosus, Systemic
  • Male
  • Prognosis
  • Registries
  • Survival Rate

Research

keywords

  • Comparative Study
  • Journal Article
  • Multicenter Study

Identity

Language

  • eng

PubMed ID

  • 17304658

Additional Document Info

start page

  • 346

end page

  • 352

volume

  • 34

number

  • 2