Nephrogenic systemic fibrosis mimicking inflammatory breast carcinoma Academic Article uri icon


MeSH Major

  • Breast Neoplasms
  • Kidney Failure, Chronic
  • Skin Diseases


  • Nephrogenic systemic fibrosis, previously known as nephrogenic fibrosing dermopathy, is a newly recognized systemic fibrosing disorder primarily affecting patients with chronic renal failure. Patients with skin involvement often develop papules and plaques with peau d'orange surface changes. The lower extremities and trunk are most commonly affected. The most important histologic differential diagnosis is with scleromyxedema. To our knowledge, we report the first case of nephrogenic systemic fibrosis involving the breasts of a 61-year-old woman with end-stage renal disease, clinically mimicking inflammatory breast carcinoma. We propose that nephrogenic systemic fibrosis be considered in the differential diagnosis as a rare possibility when cutaneous changes in the breast suggest inflammatory breast carcinoma in a patient with renal failure.

publication date

  • January 2007



  • Academic Article



  • eng

PubMed ID

  • 17227116

Additional Document Info

start page

  • 145

end page

  • 8


  • 131


  • 1