Epigenetic memory at malaria virulence genes. Academic Article uri icon

Overview

MeSH

  • Animals
  • Chromatin
  • Histones
  • Methylation
  • Transcription, Genetic
  • Virulence

MeSH Major

  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Malaria
  • Plasmodium falciparum

abstract

  • During its red blood cell stage, the malaria parasite Plasmodium falciparum can switch its variant surface proteins (P. falciparum erythrocyte membrane protein 1) to evade the host immune response. The var gene family encodes P. falciparum erythrocyte membrane protein 1, different versions of which have unique binding specificities to various human endothelial surface molecules. Individual parasites each contain approximately 60 var genes at various locations within their chromosomes; however, parasite isolates contain different complements of var genes, thus, the gene family is enormous with a virtually unlimited number of members. A single var gene is expressed by each parasite in a mutually exclusive manner. We report that control of var gene transcription and antigenic variation is associated with a chromatin memory that includes methylation of histone H3 at lysine K9 as an epigenetic mark. We also discuss how gene transcription memory may affect the mechanism of pathogenesis and immune evasion.

publication date

  • January 16, 2007

has subject area

  • Animals
  • Chromatin
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Histones
  • Malaria
  • Methylation
  • Plasmodium falciparum
  • Transcription, Genetic
  • Virulence

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1764221

Digital Object Identifier (DOI)

  • 10.1073/pnas.0609084103

PubMed ID

  • 17209011

Additional Document Info

start page

  • 899

end page

  • 902

volume

  • 104

number

  • 3