Pathologic and molecular heterogeneity in imatinib-stable or imatinib-responsive gastrointestinal stromal tumors Academic Article uri icon

Overview

MeSH Major

  • Gastrointestinal Stromal Tumors
  • Piperazines
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-kit
  • Pyrimidines

abstract

  • The histologic response to imatinib is heterogeneous and does not correlate well with clinical response. Second-site KIT mutations are rare in imatinib-responsive GISTs compared with imatinib-resistant tumors. The gene signature of imatinib-response in GISTs showed alterations of cell cycle control as well as up-regulation of genes involved in muscle differentiation and function.

publication date

  • January 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-1508

PubMed ID

  • 17200352

Additional Document Info

start page

  • 170

end page

  • 81

volume

  • 13

number

  • 1