Targeting von Hippel-Lindau pathway in renal cell carcinoma Review uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Enzyme Inhibitors
  • Kidney Neoplasms
  • Von Hippel-Lindau Tumor Suppressor Protein

abstract

  • Inheritance of a defective copy of the von Hippel-Lindau (VHL) gene leads to the most common cause of inherited renal cell carcinoma (RCC). In addition, most patients with sporadic RCC have aberrant VHL. In the absence of VHL, hypoxia-inducible factor alpha accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. We review here the biology of RCC and how a combination of proximal and distal block of VHL/hypoxia-inducible factor alpha pathway by novel targeted agents, including sunitinib, sorafenib, bevacizumab, everolimus, and temsirolimus, has led to significant improvements in progression-free survival.

publication date

  • December 15, 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-2254

PubMed ID

  • 17189392

Additional Document Info

start page

  • 7215

end page

  • 20

volume

  • 12

number

  • 24