Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity Review uri icon

Overview

MeSH Major

  • Gastrointestinal Diseases
  • Gastrointestinal Tract
  • Pain Threshold
  • Serotonin
  • Visceral Afferents

abstract

  • Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

publication date

  • January 2007

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2982.2006.00876.x

PubMed ID

  • 17280587

Additional Document Info

start page

  • 89

end page

  • 119

volume

  • 19

number

  • SUPPL.1