Predictive Value of Cell Cycle Biomarkers in Nonmuscle Invasive Bladder Transitional Cell Carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Transitional Cell
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53
  • Urinary Bladder Neoplasms

abstract

  • Combinations of p53, pRB, p21 and p27 had cooperative/synergistic effects stratifying patients into different risk groups. Higher total numbers of altered biomarkers were independently associated with an increased risk of disease progression and death. Prospective trials are necessary to usher bladder cancer management into the age of molecular biomarkers.

publication date

  • February 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.juro.2006.09.038

PubMed ID

  • 17222615

Additional Document Info

start page

  • 481

end page

  • 7; discussion 487

volume

  • 177

number

  • 2