Tracking Normalization of Brain Tumor Vasculature by Magnetic Imaging and Proangiogenic Biomarkers Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Brain Neoplasms
  • Neovascularization, Pathologic

abstract

  • Clinical assessment of the response to antiangiogenic therapy has been cumbersome. A study in this issue of Cancer Cell demonstrates that a combination of magnetic resonance imaging (MRI) for quantification of normalized vessels with measurements of circulating levels of proangiogenic factors, including FGF2, SDF1, and viable circulating endothelial cells, provides an effective means to evaluate the response of recurrent glioblastoma to a prototypical pan-VEGF receptor tyrosine kinase inhibitor, AZD2171.

publication date

  • January 2007

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2006.12.008

Additional Document Info

start page

  • 6

end page

  • 8

volume

  • 11

number

  • 1