Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: An in vitro study - Commentary Article uri icon

Overview

MeSH Major

  • Coumaric Acids
  • Glioma
  • Lactic Acid
  • Neoplasm Proteins
  • Radiation Tolerance
  • Radiation-Sensitizing Agents

abstract

  • Inhibition of lactate efflux in malignant gliomas results in alterations of glycolytic metabolism, including decreased levels of the antioxidants taurine and glutathione and enhanced radiosensitivity of ACCA-treated cells. Thus, in situ application of lactate transport inhibitors such as ACCA as a novel adjunctive therapeutic strategy against glial tumors may greatly enhance the level of radiation-induced cell killing during a combined radio- and chemotherapeutic regimen.

publication date

  • December 2006

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1227/01.NEU.0000249218.65332.BF

Additional Document Info

start page

  • 1313

end page

  • 23; discussion 1323-4

volume

  • 59

number

  • 6