Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population Academic Article uri icon

Overview

MeSH Major

  • Arthritis, Rheumatoid
  • Genetic Predisposition to Disease
  • Polymorphism, Single Nucleotide
  • Protein Tyrosine Phosphatases
  • Receptors, Immunologic

abstract

  • Our findings support an association of RA with an FCRL3 functional polymorphism and reveal that this association is stronger in the absence of PTPN22 risk genotypes. These findings support a genetic heterogeneity across RA populations, suggesting that both the FCRL3 and PTPN22 genes play roles in RA susceptibility, but in different individuals.

publication date

  • December 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/art.22270

PubMed ID

  • 17133579

Additional Document Info

start page

  • 3820

end page

  • 7

volume

  • 54

number

  • 12