Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation Academic Article uri icon


MeSH Major

  • Antigen Presentation
  • Phagocytosis
  • Signal Transduction
  • Toll-Like Receptors


  • Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed antigens by MHC class II molecules as a direct result of controlling phagosome maturation by Toll-like receptors. I discuss how the mode of antigen delivery into dendritic cells coupled with the right type of signal transduction pathway can impact greatly not only the co-stimulatory context in which the antigen is presented to naive T cells (signal 2) but MHC-II presentation of the antigen and formation of the T-cell receptor ligand (signal 1) itself.

publication date

  • January 2007



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/

PubMed ID

  • 17126600

Additional Document Info

start page

  • 19

end page

  • 25


  • 28


  • 1