Second malignancy risk associated with treatment of Hodgkin's lymphoma: Meta-analysis of the randomised trials
Neoplasms, Second Primary
Randomized Controlled Trials as Topic
Administration of CT in addition to RT as initial therapy for HL decreases overall SMR by reducing relapse and need for salvage therapy. Administration of RT additional to CT marginally increases overall SMR in advanced stages. Breast cancer risk (but not SMR in general) was substantially higher after EF-RT. Caution is needed in applying these findings to current therapies.