Novel targets in solid tumors: MEK inhibitors Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • MAP Kinase Kinase Kinases
  • MAP Kinase Signaling System
  • Neoplasms
  • Protein Kinase Inhibitors

abstract

  • MAPK/ERK kinase (MEK) inhibitors constitute a promising class of novel targeted therapies. Although some of the initial clinical results with these compounds were disappointing, newer agents with more advantageous pharmacokinetic and pharmacodynamic properties have entered clinical trials. Partial responses have been seen in patients with advanced melanoma and pancreatic cancer, along with prolonged stable disease in several tumor types. Rash, diarrhea, edema, and visual disturbances have been common toxicities. With the recent finding that cell lines with B-raf mutations are exquisitely sensitive to these compounds, the possibility of genetic-based patient selection and indiviualized therapy has been raised. Whether these predictions will be borne out in clinical testing remains to be seen.

publication date

  • November 2006

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 17143253

Additional Document Info

start page

  • 831

end page

  • 6

volume

  • 4

number

  • 11