S100 chemokines mediate bookmarking of premetastatic niches Article uri icon

Overview

MeSH Major

  • Calgranulin A
  • Calgranulin B
  • Chemokines
  • Lung Neoplasms

abstract

  • Primary tumours release soluble factors, including VEGF-A, TGFβ and TNFα, which induce expression of the chemokines S100A8 and S100A9 in the myeloid and endothelial cells within the lung before tumour metastasis. These chemokine-activated premetastatic niches support adhesion and invasion of disseminating malignant cells, thereby establishing a fertile habitat for metastatic tumours.

publication date

  • December 2006

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1038/ncb1206-1321

Additional Document Info

start page

  • 1321

end page

  • 3

volume

  • 8

number

  • 12