Preterm labor is induced by intraamniotic infusions of interleukin-1β and tumor necrosis factor-α but not by interleukin-6 or interleukin-8 in a nonhuman primate model Academic Article uri icon

Overview

MeSH Major

  • Amniotic Fluid
  • Interleukin-1beta
  • Obstetric Labor, Premature
  • Tumor Necrosis Factor-alpha

abstract

  • Preterm labor was induced by intraamniotic infusions of IL-1beta and TNF-alpha, but not by IL-6 or IL-8 although inflammatory changes in fetal membranes and lungs were uniformly present. Our results indicate a primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

publication date

  • December 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2006.06.072

PubMed ID

  • 17132473

Additional Document Info

start page

  • 1578

end page

  • 89

volume

  • 195

number

  • 6