Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Review uri icon

Overview

MeSH Major

  • Mitochondria
  • Neurodegenerative Diseases
  • Oxidative Stress

abstract

  • Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases. In all major examples of these diseases there is strong evidence that mitochondrial dysfunction occurs early and acts causally in disease pathogenesis. Moreover, an impressive number of disease-specific proteins interact with mitochondria. Thus, therapies targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria, hold great promise.

publication date

  • October 19, 2006

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nature05292

PubMed ID

  • 17051205

Additional Document Info

start page

  • 787

end page

  • 95

volume

  • 443

number

  • 7113