Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior Academic Article uri icon


MeSH Major

  • Anxiety
  • Brain-Derived Neurotrophic Factor
  • Polymorphism, Single Nucleotide


  • A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met) was expressed in brain at normal levels, but its secretion from neurons was defective. When placed in stressful settings, BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders.

publication date

  • October 6, 2006



  • Academic Article



  • eng

PubMed Central ID

  • PMC1880880

Digital Object Identifier (DOI)

  • 10.1126/science.1129663

PubMed ID

  • 17023662

Additional Document Info

start page

  • 140

end page

  • 3


  • 314


  • 5796