Idiopathic pulmonary fibrosis: prognostic value of changes in physiology and six-minute-walk test. Academic Article uri icon

Overview

MeSH

  • Aged
  • Carbon Monoxide
  • Exercise Test
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • Pulmonary Diffusing Capacity
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Vital Capacity

MeSH Major

  • Pulmonary Fibrosis

abstract

  • Idiopathic pulmonary fibrosis is a fatal disease with a variable rate of progression. We hypothesized that changes in distance walked and quantity of desaturation during a six-minute-walk test (6MWT) would add prognostic information to changes in FVC or diffusing capacity for carbon monoxide. One hundred ninety-seven patients with idiopathic pulmonary fibrosis were evaluated. Desaturation during the 6MWT was associated with increased mortality even if a threshold of 88% was not reached. Baseline walk distance predicted subsequent walk distance but was not a reliable predictor of subsequent mortality in multivariate survival models. The predictive ability of serial changes in physiology varied when patients were stratified by the presence/absence of desaturation < or = 88% during a baseline 6MWT. For patients with a baseline saturation < or = 88% during a 6MWT, the strongest observed predictor of mortality was serial change in diffusing capacity for carbon monoxide. For patients with saturation > 88% during their baseline walk test, serial decreases in FVC and increases in desaturation area significantly predicted subsequent mortality, whereas decreases in walk distance and in diffusing capacity for carbon monoxide displayed less consistent statistical evidence of increasing mortality in our patients. These data highlight the importance of stratifying patients by degree of desaturation during a 6MWT before attributing prognostic value to serial changes in other physiologic variables.

publication date

  • October 1, 2006

has subject area

  • Aged
  • Carbon Monoxide
  • Exercise Test
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • Pulmonary Diffusing Capacity
  • Pulmonary Fibrosis
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Vital Capacity

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2648064

Digital Object Identifier (DOI)

  • 10.1164/rccm.200604-488OC

PubMed ID

  • 16825656

Additional Document Info

start page

  • 803

end page

  • 809

volume

  • 174

number

  • 7