Persistent expression of autoantibodies in SLE patients in remission Academic Article uri icon

Overview

MeSH Major

  • Autoantibodies
  • B-Lymphocytes
  • Lupus Erythematosus, Systemic

abstract

  • A majority of the antibodies expressed by nascent B cells in healthy humans are self-reactive, but most of these antibodies are removed from the repertoire during B cell development. In contrast, untreated systemic lupus erythematosus (SLE) patients fail to remove many of the self-reactive and polyreactive antibodies from the naive repertoire. Here, we report that SLE patients in clinical remission continue to produce elevated numbers of self-reactive and polyreactive antibodies in the mature naive B cell compartment, but the number of B cells expressing these antibodies is lower than in patients with active disease. Our finding that abnormal levels of self-reactive mature naive B cells persist in the majority of patients in clinical remission suggests that early checkpoint abnormalities are an integral feature of SLE.

publication date

  • October 9, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2118096

Digital Object Identifier (DOI)

  • 10.1084/jem.20061446

PubMed ID

  • 16966430

Additional Document Info

start page

  • 2255

end page

  • 61

volume

  • 203

number

  • 10