Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis
Insulin-Like Growth Factor Binding Protein 5
IGFBP-5 is a key mediator of fibrosis. IGFBP-5 mediates its profibrotic effects through fibroblast activation, increased ECM deposition, and myofibroblastic transformation of dermal fibroblasts. Overexpression of IGFBP-5 provides a novel model for studying the pathogenesis of skin fibrosis in systemic sclerosis.