Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis Academic Article uri icon

Overview

MeSH Major

  • Insulin-Like Growth Factor Binding Protein 5
  • Skin

abstract

  • IGFBP-5 is a key mediator of fibrosis. IGFBP-5 mediates its profibrotic effects through fibroblast activation, increased ECM deposition, and myofibroblastic transformation of dermal fibroblasts. Overexpression of IGFBP-5 provides a novel model for studying the pathogenesis of skin fibrosis in systemic sclerosis.

publication date

  • September 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/art.22084

PubMed ID

  • 16947625

Additional Document Info

start page

  • 3001

end page

  • 10

volume

  • 54

number

  • 9