Quantitation and localization of matrix metalloproteinases and their inhibitors in human carotid endarterectomy tissues
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Tissue Inhibitor of Metalloproteinase-1
Tissue Inhibitor of Metalloproteinase-2
The spatial distribution of MMPs and TIMPs in carotid atherosclerotic lesions is highly heterogeneous, reflecting lesion location, size, and composition. This study provides the first semi-quantitative maps of differential distribution of MMPs and TIMPs over atherosclerotic plaques.