Prediction of germline mutations and cancer risk in the lynch syndrome Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Genetic Testing
  • Germ-Line Mutation
  • Models, Statistical

abstract

  • MMRpro is a broadly applicable, accurate prediction model that can contribute to current screening and genetic counseling practices in a high-risk population. It is more sensitive and more specific than existing clinical guidelines for identifying individuals who may benefit from MMR germline testing. It is applicable to individuals for whom tumor samples are not available and to individuals in whom germline testing finds no mutation.

publication date

  • September 27, 2006

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2538673

Digital Object Identifier (DOI)

  • 10.1001/jama.296.12.1479

PubMed ID

  • 17003396

Additional Document Info

start page

  • 1479

end page

  • 87

volume

  • 296

number

  • 12