Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: In vitro and in vivo correlation Academic Article uri icon


MeSH Major

  • Amphotericin B
  • Antifungal Agents
  • Aspergillosis
  • Aspergillus fumigatus
  • Liposomes
  • Lung Diseases, Fungal
  • Thiazoles
  • Triazoles


  • Combination antifungal therapy is increasingly used in the treatment of invasive aspergillosis. Whether the interaction between amphotericin B and triazoles is antagonistic against invasive aspergillosis is a controversial issue that is not likely to be resolved through a randomized clinical trial. Here, we found both in vitro and in vivo antagonism between liposomal amphotericin B and ravuconazole in simultaneous treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits. Bliss independence-based drug-interaction modeling showed significant antagonism in vitro and in vivo, with the observed drug effects being 20%-69% lower than would be expected if the drugs were acting independently. These in vitro and in vivo findings of antagonism were consistent with the findings from Loewe additivity-based drug-interaction modeling. No pharmacokinetic interaction was found. The combination of a triazole and polyene may be antagonistic in the treatment of invasive pulmonary aspergillosis.

publication date

  • October 2006



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1086/506617

PubMed ID

  • 16960790

Additional Document Info

start page

  • 1008

end page

  • 18


  • 194


  • 7