Pharmacogenomics of colorectal cancer prevention and treatment. Review uri icon

Overview

MeSH

  • Humans
  • Polymorphism, Genetic

MeSH Major

  • Antineoplastic Agents
  • Colorectal Neoplasms
  • Neoplasm Proteins
  • Pharmacogenetics

abstract

  • Pharmacogenomic tools are beginning to emerge that will provide guidance in the treatment and prevention of colorectal cancer. Significant individual genetic variation exists in drug metabolism of 5FU, capecitabine, irinotecan, and oxaliplatin that influences both the toxicity and efficacy of these agents. Recent FDA approval of genetic testing for mutations in the UGT1A1 gene that predict adverse reactions to irinotecan is ushering in a new era that will increasingly rely on genotyping to individualize treatment decisions for patients with cancer as well as for patients at high risk who may be candidates for chemoprevention agents. This review focuses on current knowledge regarding key mutations and polymorphisms which affect outcomes for colorectal cancer patients, as well as the pharmacogenetics of chemoprevention trials.

publication date

  • October 2006

has subject area

  • Antineoplastic Agents
  • Colorectal Neoplasms
  • Humans
  • Neoplasm Proteins
  • Pharmacogenetics
  • Polymorphism, Genetic

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1080/07357900600896281

PubMed ID

  • 16982469

Additional Document Info

start page

  • 630

end page

  • 639

volume

  • 24

number

  • 6